SLNB exist. The SLN reflects the histopathological status

SLNB is the ideal criteria for axillary staging in breast
cancer. A SLN is described as the first lymph node in a regional basin that
receives lymphatic drainage from the location of the primary tumor. In patients
with positive ALNs, regional control is very important. ALND can accomplish
both goals but it is recognized as the most morbid part of BC surgery. SLNB is an
alternate to ALND for staging axilla in early breast cancer patients with minimum

SLN biopsy is a reliable, means for
standard level standard level I/II axillary dissection.  The key component the lymphatic mapping that
permits the axillary nodes to assess. An
occurrence of a node to attain metastasis, the regional metastatic disease
needs to exist. The SLN reflects the histopathological status of the whole axilla,
therefore if a finding of the SNL is negative, that indications the nodal basin
to be negative as well.  In 1992,
Morton’s group tested the SNL biopsy with more than 500 melanoma patients.
Successfully removing the sentinel node, along with the remaining regional
lymph nodes. 54 The
pathology of the sentinel node claimed to show 99% accuracy of remaining
regional nodal status. Other institutes authorized complete lymphadenectomy
and histopathological examination, addition to follow-up to distinguish
potential recurrences in undissected nodal basins shadowing a negative sentinel
node biopsy. 55-57

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Giuliano et al. 19 also
illustrated the initial experience with SNL biopsy for breast cancer, by using
vital blue dye injection, it was proven by histopathological examination of the
non-SLNs. 58 By using a
technetium sulfur colloid injection and operating a hand-held ?-probe for
detection, Krag et al. 22 stated a
primary series of breast cancer SLN biopsies.

Lately, several randomized clinical
trials the SOUND 59 and NCT 01821768 60 randomized amongst SNB and non-SNB
following negative US/FNA findings including the early breast cancer patients.
Such trials revealed the prerequisite for SNB in cases with negative ultrasound
(US)-guided fine-needle aspiration cytology (FNA) of doubtful LNs. Numerous
other investigative tools were used to identify negative axillary node (cN0)
status in these trials. For example, the palpation of the axilla, the US imaging
using or computed tomography (CT), or intervention with FNA for suspicious LNs.
Hence, a significant thought for an exclusion of SNB or ALND differs on an
extremely accurate preoperative staging for axillary LNs assessment.


 Our study shows that core biopsy had greater
sensitivity than FNA in detecting metastasis, it could approach statistical
significance. Our study also reported three vital findings. Primary, the high
accuracy rate of CNB between preoperative diagnostic axillary staging and final
histological findings, representing the superiority of CNB over FNA. Following,
the objective predictors of decisive pathological negative node status were
related to the clinical characteristics of breast cancer and the investigative
means used to assess the axillary LNs. Lastly, our study also found that CNB
for axillary staging in terms of safety and simplicity was parallel to FNA

 In this current study, we found
out during the US findings, abnormal LNs among the breast cancer patients while
a negative CNB result had a comparatively lower rate of positive LNs and a
lower rate of non-SLN metastasis than patients with a negative FNA. The
accuracy of FNA and CNB compared to the final histological diagnosis of LNs was
90.8% in FNA while 96.2% in CNB. Precisely, Sensitivity was 76.0% in FNA and
90.0% in CNB and positive predictive value of FNA 87.2% and CNB 94.2% (Table

Our study
comprised several skilled surgeons and allowed a variety of sampling devices to
simulate actual clinical practice. While axillary node FNA is technically easy
to perform for one skilled in image-guided procedures, the surgeons must obtain
an aspirate that is both adequate in the amount of material and at the same
time not overly bloody, to enable an optimal interpretation. It is uncertain
why there were less false negative results when multiple FNA entries were attained,
as the total number of needle excursions likely did not differ greatly. Perhaps
the chance of achieving a better sample was improved by using different entry
sites or achieving less blood mixed with cells from the node. The quantity of
slides used, the actual number of excursions and length of procedure were not noted,
which could have affected the results. In some institutes, a pathologist is
present when cytologic samples are acquired and can request extra sampling if
the specimen is expected suboptimal; the presence of a pathologist at the period
of sampling could have improved from FNA and CNB. In our hopital, immunostains
may be used to aid in interpretation when FNA alone is performed. Our
pathologists have extensive experience in cytopathology but in this study,
there were no immunostains used in the cytologic evaluation; because the
pathologists knew that additional tissue would be studied by core biopsy, a
reason that may have decreased the sensitivity of FNA. Amongst patients with
breast cancer, US-guided core needle biopsy of axillary lymph nodes can yield a
high accuracy rate with no substantial complications.

      The size of a best lymphatic tracer
should be (in the range of 50–200 nm)big enough to remain in the sentinel lymph
nodes, small enough to allow its entry into the lymphatic capillaries while
long enough for proper SLN visualization and imaging without being transferred
to the higher tier nodes early.61-63 For the SLNs to be properly recognized
during the surgical procedure, the Nano-sized carbon particles with a diameter
of 150nm pass easily through the lymphatic capillaries and also allows
accumulation in the lymph nodes for the longer duration. In comparison, the
molecules of blue dyes are pretty small (